The City of Willoughby Hills is bordered by the City of Richmond Heights (Cuyahoga County), to the West, The Villages of Mayfield  and Gates Mills (both in Cuyahoga County) to the South, Kirtland (Lake County) to the East, and the Cities of Willoughby and Wickliffe (Lake County) to the North.  

The center of the City is located at the intersection of Chardon Road (U.S.6) and SOM Center Road (Ohio S.R. 91).  The City's primary retail district is located at the intersection of Chardon and Bishop Roads, just South of I-90.

Two interstate highways join together in Willoughby Hills.  I-90 passes through from East to West and I-271 splits from I-90, going South to bypass Downtown Cleveland and ultimately connecting to I-71. 

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